I will try to word this question so it makes sense.
I have 4160v multi-conductor cables with 480v multi-conductors in the same ladder type ventilated cable tray. My first though was to size the tray based on 392.22(A)(1)(b). But after some thought I have spaced the 4160v cables per 392.80(B)(1) which then spaces cables in a single layer with maintained spacing of not less than on cable diameter between cables. I then subtracted that spacing from 36" width which is the tray size I am using. The remainder of the tray width I will use to determined if the tray size is adequate based on the sum of the cross-sectional areas of all cables smaller than 4/0 that do not exceed the maximum allowable fill area in column 1 of table 392.22(A) for the appropriate tray width.