I myself do not depend upon just one scanner for total protection.
While Trend Micro Titanium is my main scanner (only because it can be set to fort Knox lock my computer from many web sites I don't want it to go)
But that it also has a nice feature for e-mail where it scans my e-mail before it gets to my in-box (still use outlook express) it also blocks any link in a e-mail or web site that is listed as bad.
The only thing I don't like is that this year it didn't include a fire wall, so Zone Alarm is back in, which
Steve Gibson GRC.com helped create great guy one of the biggest security guru's I know.
For backup I use a combination of dormant scanners ( like in ones I don't have running all the time)
Malware Anti-Bites is the first one I scan with if trend doesn't find anything
Ad Aware by Lava Soft is my next scan, Steve Gibson had a scanner but since Lava Soft had Ad Aware out and he checked out he backed off in developing his own and offered his research to them to use as he liked the product.
Kaspersky is my last one I have, and I also use their root kit killer (TDSS killer) as it is second to none for root kits.
Also I am a member of
Malware University which has
Malware Removal forum that anyone who has a virus can get help with finding it and removing it, they will teach you how to do it and they will give you the tools, it can be tedious as it is in a forum format and like here you have to wait for the responses, but it is a great site that people are helping combat the threats we have on the internet, they are also the ones who developed Malware Anti bites, it is also where I learned how to use the program "Combo Fix" again just don't find this program on the internet and run it without knowing how to use it, this program is very powerful and can cause much damage in the wrong hands, it can wipe system files and you will have to rebuild them if you don't follow your instructor.
Malware Removal has rules, because of liability they will not help you fix a computer if it is used in the course of a business, if it is a work station on a work network, or if you do not have admin permission on that computer, they will not waste their time if their scans show you are using any peer to peer programs as this is number one reason many get infected, but if it is just a personal computer and you need help it is free (donations accepted) and they will walk you through on how to find and remove almost every kind of virus/malware out there, but the most important thing is to read the rules and instructions and follow the persons instructions helping you to the letter do not jump ahead even if you think you already know what to do.
I have used them to help me fix many of my friends computers, and since I know a few of the mods on there one of them helped me find the root kit I had a few weeks back but because of the forums rules he had to help me through e-mails as this computer is also the one I use for my B&W Electric company.
I think those guys on there are great as they do it just to help people without even getting paid anything, there is still some good people in this world, I have the same feelings for the people of Mike Holt as I have learned so much from here, and I think it is great that we share our knowledge with those who are just getting into our field, over the years I have run into so many who think they know something but wont share it with anyone, and that is sad, teaching has its rewards, and when you have helped someone there is no other feeling like it when you give some of it back.
Pass your knowledge on, as it is better to leave it behind then try to take it with you when your gone.