If you have single phase loads that need the line-to-line voltage, 2-pole breakers are the thing to use. If you have several of these loads that are the same or nearly so, using 2-pole breakers side-to-side will help balance the load on the 3-phase.
For instance if you have a group of 208V window air conditioners on 208/120 service, you can hook them up on:
(position-phase position-phase)
1-A 3-B = A/C 1
5-C 7-A = A/C 2
9-B 11-C = A/C 3
This puts two units each on phases A, B and C.
Using 3-pole breakers requires 50% more space and for you to manually rotate the empty pole to accomplish the same thing.
[unused]
1-A 3-B [5-C] = A/C 1
7-A [9-B] 11-C = A/C 2
[13-A] 15-B 17-C = A/C 3
This same scheme would apply if the loads involved the neutral (clothes dryers for example).