It appears you are in the UK, so we’ll give you a pass...
It will have to start with whether your equipment is “double insulated”, or needs a ground pin.
Three pole 220 (208 to 250) Volts with ground, L15-20.
As above, but with Neutral, a 5 wire cord, L21-20.
I guess basically what I'm asking is does the 208V quoted voltage of the L21-20P prevent the use of it on a 220V supply?
Does the quoted voltage of 250V of the L15-20 prevent the use of it on a 220V supply?