Depends on what you are calling initiating and signaling. A signaling line circuit (SLC or addressable) can sometimes cause problems on other circuits such as speaker circuits if they are too close. Some 70 volt speaker circuits are considered non power limited and required to be separated from the power limited circuits such as pull stations, smoke detectors etc. Normally, power limited and non power limited have to be in different conduits.
Even if code allows you to run circuits in the same conduit or cable, some manufacturers will not support you if you have technical issues when certain circuits are in the same conduit. You should follow the instructions of the manufacturer of the system you are installing today and not install it the way you have always done it on previous jobs or the way another system is always installed.