Protecting against lightning is more then just installing TVSS equipment, allot of it has to do with how you run your conductors in the structure, and how the different systems enter the house from outside, it can be very costly and add many hours to wiring a house or business, first having all you systems like cable, phone, and power enter at one point is a start, building a ground ring for them to enter through is even better, also how you run run you conductors and the paths they take inside can make a difference on near field strikes, running home runs together till the point they go to their respective devices can cut down on multi-paths that can act like a transformer winding with near field strikes, oh and TVSS don't protect against near field strikes.
The idea is to group your power and signal pathways so they act as one conductor when in the field of a lightning strike, as we know current can not flow on just one conductor, the worst installs I have seen was where you have an entertainment system on one side of a room plugged into one circuit and a sub amp on the other side of the room plugged into another circuit that takes a whole different path back to the panel, with the audio cable inbetween, this allows a loop that the near field strike can set up eddy currents into these paths putting a high voltage potential between the sub amp and the entertainment equipment which can result in destroying the sub amp, and or the I/O board in the entertainment system, also I have seen where the audio cables running between them are vaporized, but since this would be impossible to do after a house is done being wired, the best you can hope for is to install TVSS at both the main panel and the load end, and not just one circuit, having a few TVSS units around the house can act together to build up a more robust protection over all, by making sure you have at least a couple on each phase of the service, having TVSS at the load end is important as lightning and or transients are high frequency events, and impedance of conductors can be very high which does not allow the TVSS to protect very far down a circuit, so this is why having protection at the panel and load end is important.