First of all, it isn?t a question of advantages versus disadvantages. The NEC requires that the load be balanced. But you don?t need to strive for perfection, in the process of balancing your loads. You don?t need to worry that Phase A is loaded 1% higher than Phase B.
The simple answer to your question is that the rating or size of electrical components (e.g., conductors or panels) is determined on the basis of load calculations. The calculation process presumes that a reasonable effort will be made to balance the loads. If you don?t have a reasonable balance, then the amount of current flowing in one phase might be so much higher than the amount flowing in another phase that the selected conductor size might not be big enough to handle the current. Than runs the risk of overheating the conductor, causing damage to the insulation, short circuits, and fires.