Diagnosis of this is going to require detailed information, ideally from someone experienced with electrical work on site during the problem.
The OP is not an electrician, but lists their occupation as industrial maintenance, so I'd consider them clued in. It sounds like there is a professional electrician involved as well. It would be great if the electrician could be part of this conversation.
Which appliances are turning themselves on?
What is the total draw of these appliances relative to the breaker capacity?
Does the house have a number of high draw appliances which normally start at different times (eg a well pump, large central AC, other motors)?
Do these appliances have remote control capabilities (WiFi, apps, remote thermostats, ...)?
What is the order of events? Does the breaker trip first or do the appliances come on first, or does it vary?
What is the model of thermostat that turned itself to 99?
Is there any monitoring? (Electrical system, cameras, people?)
Do the events happen when the OP is present, or do they occur and are then later discovered by the OP?
Jon