The voltage drop exists but isn't normally much of a problem in residences because the home runs that are usually the longest go to bedrooms which usually aren't heavily loaded. The big guns like the kitchen, water heater and a/c systems usually are closer to the panel. I've never had an inspector even say voltage drop to me.
That said, if you know you are going to put in a particularly long run, (say to a hot tub on the other side of the house), it would be a good idea to calculate VD and upsize wiring if needed.