I'll answer your question with an example I ran into last week.
The 125VDC was ungrounded and fed a distribution panel that had all single pole breakers on the + bus. Negative wires to the loads were directly connected to the negative bus. The electrician locked out the pump circuit by opening the breaker and tagged it.
While he was working in the pump panel, an accidental ground was applied to 125VDC positive bus. That forced the negative bus to -125VDC to ground. All the "de-energized" wires inthe panel now became hot with 125VDC. A few sparks occurred and some wires melted, but fortunately no injuries. We changed to 2-pole breakers.
At 1,000 VDC, there may be some injuries if you only fuse one leg and that leg gets grounded. Either ground the negative bus, or use two-pole brekaers or two fuses. No unprotected wires.