Most of what we call MCCBs (Molded Case Circuit Breakers) sold for simple load centers and panelboards are Thermal Magnetic “fixed trip” breakers, meaning the trip settings are set and tested by the factory and NOT field adjustable. So that statement would not apply in probably 99% of applications where you would see a 225A Main Circuit Breaker on a panel.*
When you get into “industrial” and larger commercial systems where coordination might be more critical (and your budget can afford them), you can get MCCBs with Electronic Trip Units (ETUs) that allow you to set the trip values in the field. Traditionally those were only available in 400A frames and above, but more recently the concept has crept down into 100A frames too, plus the cost difference has dropped to where they are more affordable in larger frames. The danger in having adjustable trips is in someone responding to a tripped breaker by increasing the settings. The theory is that in an industrial / large commercial setting “under engineering supervision”, where there are established policies against doing such a thing, that’s less likely to happen. In theory...
The spec you are reading is likely an indirect way for the engineer to discourage their use, because having to have every one of them certified via primary injection testing after installation will make it very unlikely that the cost can be justified without someone explaining the risk/benefit situation to those paying the bill.
* Side note: The term “MCB” has multiple meanings now. I’m assuming by context that you meant Main Circuit Breaker, but it also stands for “Miniature Circuit Breaker” in the rest of the world and now has crept into our lexicon too. So we should all think about how we use that acronym now by making sure we include clear context.