Re: Wiring my house
This can be more complicated than you imagine. You have not provided enough details of exactly what members you plan to drill through and what these members are being used for. Building codes govern how many, how big, and where holes may be drilled into wood members.
In some cases, drilling or cutting into wood members requires a detailed and approved specification by the structural engineer.
Assumming you are talking about round holes and not notches, I will provide a basic guidline.
For horizontal joists, holes shall not be within 2" of the top or bottom of the joist, and the diameter of the hole shall not exceed 1/3 the depth of the joist.
For vertical members, holes shall not be more than 40% of the width of any stud, or 60% the width of a nonload bearing wall. Holes shall not be located within 5/8" of the edge of the member or it will be considered a notch.
Holes can be up to 1 3/8" in any 2x4 stud, or up to 2 1/16" in a nonload bearing wall.
Nail plates should be used where the hole is within 1 1/4" of the edge of the member, top plate holes require 1/8" steel plate at least 1 1/2" secured with not less than 4 - 16 penny nails.
Truss members and components should never be drilled unless details are provided by the structural engineer.
Please review your local building code and get engineering assistance before any drilling is performed.