How so?
E.g. #8 Cu has a 75C ampacity of 50A at 30C ambient. So if I connect some pieces of it together with some 75C wirenuts, and I run 50A through the whole assembly forever at 30C ambient, the equilibrium temperature of the system should be less than 75C everywhere. [Or if the wirenuts create a hot spot because of the contact resistance of the connection, presumably the actual allowable temperature of its materials is higher than the 75C rating of the wirenut.]
And if I have a 100% rated 50A breaker in its special enclosure (if such a thing exists), then you could land your #8 Cu on it and run 50A through the circuit forever and the breaker shouldn't trip.
But if I have a regular 50A breaker in a panelboard full of other breakers, then even in a 30C ambient there's apparently a possibility the heat generated from that continuous 50A current (and conductor operating at up to 75C) will skew the breaker trip curve and cause it to trip below 50A. As a result, the NEC inserts various 125% continuous use factors as required (and I would argue in some cases where not required) to keep that from happening.
Cheers, Wayne