Whether or not you need a fuse.
Some equipment have only fuses on their nameplate. If you feed it from the panel with a breaker, you'll need to install fuses to protect the equipment.
Other times, it's a job specification. Many times, EEs upsize wires feeding large loads to reduce voltage drop. You may see an RTU fed with #2 on a 100a breaker, but 80-amp fuses in the disco. The 100a breaker protects the wiring, the 80a fuses protects the RTU.