I can say this, at my previous place of employment they decided to try and save on some unneeded lighting so they had us remove the tubes in several lights. Then later (few months-1 year) the lighting was needed and when the tubes were put back over half of them the ballast had to be replaced. These were the old magnetic types. I don't have any proof that removing the tubes caused it, nor do I know if it could harm them. These ballasts could have been on the brink of going out before the tubes were removed. I just found it odd that so many went out at once.