Use quickbooks and use their payroll service!
We've used quickbooks for years and used their tax tables to do our own payroll, and had our accountant do the quartlies.
Well, somewhere along the line he made a mistake. After repeatedly thinking it was fixed, then getting IRS letters, late fees, etc. we found out that a mistake was made 4 years ago and the accountant was not correcting it properly. Instead, he was pulling payments from the next quarter and applying it to the previous. Vicious cycle as we were paying penalties, paying accountant to fix, in a revolving cycle. It's finally been rectified.
We switched to Quickbooks payroll where they do quartlies, W2's etc. They are also responsible for any mistakes.
My sister in law is a CPA, and CFO for a 150 million dollar company in NJ, and they use quickbooks payroll. She swears by it, and has had plenty of experience with the IRS.