Application requirements might be what would have objections to splicing a shielded cable, presuming you are asking about a shielded cable.
Will it work, likely yes. will it allow signal interference that wouldn't be there if unspliced, possibly.
kind of comes down to what kind of signal interference can be tolerated by the specific application.
Some applications if you happened to damage the cable and wish to splice it back together, at very least may need to recalibrate for any changes in the cable for the most accurate results. This can be critical with items that need high precision with the signal being sent. Even trimming off excess cable length might require recalibration in some applications.