Okay. If all the B spaces on the panel are blanked off, then you don't have a problem there. The issue would be if you had 120/240V 'slash rated' breakers on the B space. So not a problem.
If you have a 3 phase transformer with separate primary and secondary windings (a common 'isolation transformer', usually with a delta primary and a wye secondary), then the fact that the source is a high leg delta won't cause any issues.
The title of your thread causes a bit of confusion, because 'buck-boost' generally implies an autotransformer arrangement, where one set of coils serves both primary and secondary function with different taps. Depending upon the precise load requirements, you might be able to use an autotransformer setup. The high leg will not cause any problems with the line-line voltage of the output, but will certainly mean the output is not balanced relative to ground.
In your OP you ask about voltage stability. This is worth investigating a little further. _Some_ high leg systems have a relatively small (high impedance) transformer providing the third leg. This means that its voltage will drop more than expected under load. So you may need to confirm that the voltage stability of your 240V high leg service is suitable for your load.
-Jon