No, it won't do anything useful.
Back in the day*, you could malcalibrate the engine-temperature sensor and fool the brain box into enriching the mixture by reporting a temperature lower than the actual temperature. But that doesn't work with modern* cars; the algorithms are more sophisticated and do more cross-checking. About all you're likely to do is induce a fault code.
For example:
Estimate the outside-air temperature by measuring the intake-manifold air temperature a few moments after starting. Compare that with the coolant temperature and oil temperature, and watch how fast they rise. If one of them doesn't rise proportionally to the other, (or doesn't rise at all) flag it as a failed sensor.
With modern closed-loop control, the exhaust-gas oxygen sensor is continuously monitored to set the mixture. If there's oxygen in the exhaust, (which would cause NOx formation) the brain box adds a little more fuel the next time. If not, (which would cause CO formation) a little less. Using this method, the air:fuel mixture is never exactly stoichiometric, but it's always really, really close.
The algorithms are capable of measuring the exhaust-gas oxygen content (and inferring the air:fuel mixture) of each cylinder with a single O₂ sensor by precisely timing just when the O₂ measurement is made. The measurement is made at the moment when the exhaust gas from the desired cylinder is flowing over the O₂ sensor. (the downstream O₂ sensor is used to validate the catalytic converter's performance)
* My apologies; I'm not sure when, exactly this happened. Late 1980s?