Could easily be someone made a mistake and crossed a neutral with an equipment grounding conductor at some piece of equipment, or damaged insulation on a neutral conductor is contacting a grounded object in some remote location, could be pinched by a box cover or something really simple like that, but could take hours or even days to find it.
I am thinking if the sub refrigeration panel is causing the ground leakage current. One easy way to check is as stolz suggested. But what if the shut down of refrigeration plants cause other problems and not allowed? In that case I think measuring the voltage drops at various points on the sub panel grounded surface, and few upstream and downstream ground points with respect to remote ground i.e at the main bonding jumper and without disconnecting the EGC will provide the necessary clue.