Basically the way I do these is like the POCO would, typically a 25KVA transformer. We all know the NEC calcs are highly excessive and way outside of reality, so if you have a picky AHJ that wants NEC sized equipment, this can result in much higher costs unfortunately. That said, the NEC deosnt address transformer sizing, so you can "undersize" your transformers to a more reasonable 25KVA size with less cost and less losses, and have the protection values in 450.3 probably still meet the NEC calculated Loads.
AS far as Voltage drop, Most houses will not see over 60-70 amps, even if all electric, so that is the figure I use to calculate wire size. So using that, I only get 2 sets of 250 AL or 1 set of 750 AL for under 3% at 70 amps. Staying under 500KCMIL is much more efficient because skin effect starts to come into play. Remember you transformers will have voltage drop also, so be "fair" in your analysis and if you are figuring 3% for the VD for the wire with a step up step down, that is probably the same as say 6% without the transformers. I just hate to see money wasted on excessively large wire.