I don't know if you can calculate it so easily.
The worst loads are relatively large uncorrected DC power supplies like older computers. If you have three 100W, 200VA computers each connected to its own phase, you'd think it balances out in neural but the neutral doesn't cancel out the current and you can end up with more current than any of the individual phases.
Although power factor and harmonics have always been kept in control for lighting ballasts, so that issue seldom affects lighting circuits. What's the spec on the luminaires?
it is reasonable for order of magnitude and our purposes
http://www.geappliances.com/email/lighting/specifier/downloads/Total_Harmonic_Distortion.pdf
In four wire WYE systems such as 120/208 and 277/480-volt systems; harmonicsmay cause a problem with overheating of the neutral wire. The phase wires shouldalso be designed for the increased harmonic current, but since the “triplens” areadditive, the problem is especially critical on the neutral. The third harmonic andother “triplens” (9th, 15th, etc.) are additive. Total Harmonic Distortion is thepercentage of all of these additive values in relation to the total load. The sum oftriplen harmonics greater than 33 percent will result in neutral current greater than individual line currents. The resultant current exceeds the neutral conductor’s ratingand causes overheating of the neutral and/or transformer.